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ACTH 11-24

CAS No. 4237-93-8

ACTH 11-24( Adrenocorticotropic Hormone (11-24) )

Catalog No. M29947 CAS No. 4237-93-8

ACTH (11-24) is a fragment of adrenocorticotrophin, induces cortisol release. ACTH (11-24) has been identified as a competitive antagonist of ACTH (1-39) and ACTH (1-10) in isolated adrenal cells.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    ACTH 11-24
  • Note
    Research use only, not for human use.
  • Brief Description
    ACTH (11-24) is a fragment of adrenocorticotrophin, induces cortisol release. ACTH (11-24) has been identified as a competitive antagonist of ACTH (1-39) and ACTH (1-10) in isolated adrenal cells.
  • Description
    ACTH (11-24) is a fragment of adrenocorticotrophin, induces cortisol release. ACTH (11-24) has been identified as a competitive antagonist of ACTH (1-39) and ACTH (1-10) in isolated adrenal cells.(In Vitro):ACTH (11-24) acts as an antagonist of adrenocorticotropic hormone receptor. ACTH (11-24) induces cortisol secretion submaximally in freshly dispersed or cultured beef adrenal cortical cells. The maximal cortisol release by ACTH (11-24) is enhanced by forskolin but inhibited by calcium channel blockers.(In Vivo):ACTH (11-24) blocks electroacupuncture (EA) anti-edema but not EA anti-hyperalgesia in rats.
  • In Vitro
    ACTH (11-24) elicits cortisol secretion submaximally in freshly dispersed or cultured beef adrenal cortical cells.
  • In Vivo
    ACTH (11-24) has slight influences on circulating plasma corticosterone values and on fighting behavior.
  • Synonyms
    Adrenocorticotropic Hormone (11-24)
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Adrenocorticotropic hormone receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    4237-93-8
  • Formula Weight
    1652.04
  • Molecular Formula
    C77H134N24O16
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 100 mg/mL (60.53 mM)
  • SMILES
    ——
  • Chemical Name
    Sequence:Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

Li ZG, et al. Adrenocorticotropin(1-10) and -(11-24) promote adrenal steroidogenesis by different mechanisms. Endocrinology. 1989 Aug;125(2):592-6.
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